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Zyderm and Zyplast are injectable collagen treatments derived from bovine collagen. The first collagen implants to be approved by the FDA, millions of people have used Zyderm and Zyplast to enhance the appearance of their face by filling in fine lines and wrinkles.

Length of Surgery

30 minutes




Topical anesthetic, or lidocaine contained in injection

Back to work in...


Back to the gym in...

1-2 days

Treatment Frequency

3-6 months


Redness, tenderness, bruising, allergic reaction


$300 to $800

Duration of results:

3 to 6 months

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Click links below for detail.

Zyderm and Zyplast costs

Zyderm and Zyplast costs are less than many other dermal fillers, although the effects usually do not last as long. Treatments usually start at $300 per cc. More than one cc may be required depending on the size of the treatment area and the effect desired. There may also be an additional charge, up to $150, for the required allergy test.

Am I a candidate for Zyderm and Zyplast?

Collagen injections are a popular choice for women and men between the ages of 30 and 65 who are seeking to reduce the visible signs of aging and improve the appearance of facial skin. Most patients choose Zyderm and Zyplast collagen injections for the treatment of:

  • Frown lines (glabellar lines)
  • Crow's feet around the eyes (periorbital lines)
  • Smile lines (nasolabial folds)
  • Acne scars

An allergy test must be administered approximately 4 weeks before the injection of Zyderm and Zyplast. Approximately 3 percent of potential candidates are allergic to the bovine collagen used in these dermal fillers. In addition, this treatment should be avoided by women who are pregnant or breastfeeding, as well as those with a known sensitivity to lidocaine or a history of autoimmune disease.

What are Zyderm and Zyplast?

Both Zyplast and Zyderm are made of purified, bovine-derived collagen. Zyderm is formulated to improve fine lines such as crow's feet, subtly smoothing the area for a more youthful appearance. There are two concentrations of Zyderm; Zyderm 1 is formulated for the treatment of fine lines and wrinkles on thin-skinned areas, while Zyderm 2 is recommended for moderate lines, wrinkles, and scars. Zyplast is used on deeper lines, such as worry lines or frown lines, to add volume to the lips or cheeks, and for treatment of thicker-skinned areas.

Zyderm and Zyplast steps

Because Zyderm and Zyplast are derived from bovine collagen, an allergy test is required several weeks before the collagen is injected in the skin. This spot test must be watched for signs of an allergic reaction.

The injection itself takes just a few minutes in the doctor's office. This procedure is relatively painless because the collagen gel contains lidocaine, a numbing agent. An anesthetic cream may also be applied prior to the injection. The doctor uses a very thin needle to inject a small amount of collagen gel into the target area. Several injections may be required depending on the size of the treatment area and the depth of wrinkles.

Zyderm and Zyplast Recovery and Healing Steps

Following the injection of Zyderm or Zyplast, you can return to your daily activities immediately, with no downtime. Some patients even schedule the treatment during their lunch break. Results are visible immediately after the injection.

Zyderm and Zyplast Side Effects and Procedure Risks

Collagen injections such as Zyderm and Zyplast are generally very safe. Common side effects of collagen injections include redness, swelling, or bruising at the site of the injection, which should subside within a day or two. Rarely, allergic reactions may occur, particularly if the spot test wasn't watched closely enough prior to the injection.

Skin Rejuvenation Checklist

Skin Rejuvenation Checklist

Knowledge is power so arm yourself with the facts before making any decision about Zyderm and Zyplast procedures; click here for an essential check list to help you find the right Perfect Yourself skin specialist.

Most popular procedures on Perfect Yourself: liposuction, breast augmentation, face lifts, rhinoplasty, tummy tucks
Be sure to also visit our Expert Advice page where you can find great questions from real visitors, Answered by real plastic surgeons, cosmetic dentists, and skin rejuvenation specialists.